|::: CME Corner : Department of Biochemistry|
AN UPDATE ON CURRENT APPROACH TO CARDIOVASCULAR DISEASES
The Department of Biochemistry, Coimbatore medical college
New lecture hall, Coimbatore medical college hospital
Total number of participants
300 (including I MBBS, II MBBS, PG students, faculty members)
Approved by the TN Dr MGR Medical University for 5 credit points under Category II
AIM AND OBJECTIVES
Cardiovascular diseases like Myocardial Infarction and Cardiac Failure are some of the commonest causes of mortality and morbidity worldwide. Due to the increased prevalence of these conditions in the society, it is imperative that the medical community is aware of the recent trends in the presentation and management strategies of cardiovascular diseases.
Through this CME programme, we aim to impart essential basic knowledge of metabolism of heart and the biochemical markers of heart diseases in the minds of undergraduate students.
Also, this program aims to provide an update on the current trends in treating cardiovascular conditions so the postgraduate students and practitioners will get benefited.
|Cardiac Biochemistry and markers of ischemia
||Dr. Meenakshi Sundaram, A.S, MD
Assistant Professor of Biochemistry, PSGIMSR
|Diagnostic and prognostic value of novel cardiac markers in heart failure
||Dr. C. Shanmugapriya, MD
Professor and HOD of Biochemistry,
Govt Thoothukudi Medical College
|Acute Coronary Syndrome- A practical approach
||Dr. J. Nambirajan, MD, DM
Head of the department of Cardiology,
Coimbatore Medical College
CARDIAC BIOCHEMISTRY AND MARKERS OF ISCHEMIA
Dr. Meenakshi Sundaram.A.S.,MD.,
The heart muscles primarily rely on fatty acid oxidation for energy production in the form of ATP. The metabolism and contractility of the heart changes after an injury due to ischemia. There is an increase in lactate production and the phosphocreatine:ATP ratio, accompanied by the release of various compounds in the bloodstream that can serve as diagnostic and prognostic indicators of the event.
The most widely used cardiac markers in practice are the cardiac troponins and creatine kinase- MB fraction. Adjunct markers include myoglobin, Lactate dehydrogenase, Aspartate transaminase, NT- pro BNP, among others.
DIAGNOSTIC AND PROGNOSTIC VALUE OF NOVEL MARKERS IN CARDIAC FAILURE
Heart failure is a major illness and cause of death in industrialised countries. Due to the paucity of specific clinical manifestations, its early diagnosis and management might be challenging.
Recent advances in cardiac failure bio marker studies promise for enhancing the traditional methods of assessing the affected patients. B type natriuretic peptide (BNP) and its biologically inert, amino terminal propeptide (NT- proBNP) have become an essential component in the diagnosis and determining prognosis of cardiac failure.
A few other valuable markers of myocyte strain include Adrenomedullin, Atrial natriuretic peptide (ANP), mid regional fragment of the pro hormone (MR- proANP), sST2 and Galectin.
ACUTE CORONARY SYNDROME – A PRACTICAL APPROACH
Coronary artery disease is characterised by atherosclerosis in coronary arteries and often leads to coronary heart disease. It is attributable to one thirds of all adult deaths.
Coronary artery disease exerts a lot of additional pressure on existing health care system. In India, it is characterised by early age of onset, higher disease severity and mortality and enormous impact on productive life years. Innovative primary prevention and tailored secondary prevention strategies by utilising maximum available resources maybe useful for decreasing its incidence in India.